Overview

Basic information

Litigation

Active legal matters

Material Events

8-K disclosures

SEC Filings

Key regulatory docs

Insider Transactions

Ownership changes

Overview

Basic information

Litigation

Active legal matters

Material Events

8-K disclosures

SEC Filings

Key regulatory docs

Insider Transactions

Ownership changes

Historical Insider Transactions

The table below lists insider purchases and sales reported by company officers, directors, and major shareholders during the last 12 months.

DATE

INSIDER

INSIDER TYPE SHARES PRICE

SHARES

PRICE

VALUE

Aug 04, 2025

Valamehr Bahram

Valamehr Bahram
President and CEO
Sell
14,466 $1.06

14,466

$1.06

$15,396

Aug 04, 2025

TAHL CINDY

TAHL CINDY
See Remarks
Sell
9,037 $1.06

9,037

$1.06

$9,573

Jan 10, 2025

Valamehr Bahram

Valamehr Bahram
President and CEO
Sell
8,705 $1.54

8,705

$1.54

$13,406

Jan 10, 2025

TAHL CINDY

TAHL CINDY
See Remarks
Sell
5,654 $1.55

5,654

$1.55

$8,764

Jan 10, 2025

Bressi Jerome Charles

Bressi Jerome Charles
See Remarks
Sell
5,980 $1.55

5,980

$1.55

$9,269

Dec 20, 2024

Redmile Group, LLC

Redmile Group, LLC
Sell
341,633 $1.68

341,633

$1.68

$573,943

Dec 20, 2024

Redmile Group, LLC

Redmile Group, LLC
Buy
397,964 $1.68

397,964

$1.68

$668,580

Aug 06, 2024

Xu Yuan

Xu Yuan
Sell
633 $4.23

633

$4.23

$2,678

Jan 29, 2024

Dulac Edward J III

Dulac Edward J III
CFO
Sell
1,849 $5.00

1,849

$5.00

$9,245

Jan 09, 2024

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
14,391 $4.37

14,391

$4.37

$62,889

Jan 09, 2024

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
11,271 $4.38

11,271

$4.38

$49,367

Jan 09, 2024

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
10,874 $4.37

10,874

$4.37

$47,519

Jan 09, 2024

Dulac Edward J III

Dulac Edward J III
CFO
Sell
7,028 $4.37

7,028

$4.37

$30,712

Dec 26, 2023

Redmile Group, LLC

Redmile Group, LLC
Buy
44,630 $3.72

44,630

$3.72

$166,024

Nov 09, 2023

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
24,363 $2.40

24,363

$2.40

$58,471

Aug 18, 2023

Dulac Edward J III

Dulac Edward J III
CFO
Sell
4,718 $2.80

4,718

$2.80

$13,210

Aug 04, 2023

Xu Yuan

Xu Yuan
Sell
632 $3.71

632

$3.71

$2,345

Jul 05, 2023

Dulac Edward J III

Dulac Edward J III
CFO
Sell
5,182 $4.83

5,182

$4.83

$25,029

Jul 05, 2023

Powl Brian T.

Powl Brian T.
Chief Commercial Officer
Sell
3,854 $4.87

3,854

$4.87

$18,769

Jun 14, 2023

Xu Yuan

Xu Yuan
Sell
3,460 $5.58

3,460

$5.58

$19,307

Apr 21, 2023

Redmile Group, LLC

Redmile Group, LLC
Buy
256,639 $6.18

256,639

$6.18

$1,586,029

Apr 20, 2023

Redmile Group, LLC

Redmile Group, LLC
Buy
20,000 $5.99

20,000

$5.99

$119,800

Apr 18, 2023

Chu Yu-Waye

Chu Yu-Waye
CMO
Sell
215 $6.52

215

$6.52

$1,402

Apr 18, 2023

Chu Yu-Waye

Chu Yu-Waye
CMO
Sell
2,317 $6.58

2,317

$6.58

$15,246

Apr 14, 2023

Redmile Group, LLC

Redmile Group, LLC
Sell
302,339 $5.84

302,339

$5.84

$1,765,660

Apr 14, 2023

Redmile Group, LLC

Redmile Group, LLC
Buy
25,700 $6.00

25,700

$6.00

$154,200

Jan 13, 2023

MENDLEIN JOHN

MENDLEIN JOHN
Buy
36,631 $5.43

36,631

$5.43

$198,906

Jan 11, 2023

MENDLEIN JOHN

MENDLEIN JOHN
Buy
88,048 $5.67

88,048

$5.67

$499,232

Jan 10, 2023

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
45,907 $5.24

45,907

$5.24

$240,553

Jan 10, 2023

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
10,917 $5.24

10,917

$5.24

$57,205

Jan 10, 2023

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
11,553 $5.24

11,553

$5.24

$60,538

Jan 10, 2023

Dulac Edward J III

Dulac Edward J III
CFO
Sell
7,331 $5.24

7,331

$5.24

$38,414

Jan 10, 2023

Chu Yu-Waye

Chu Yu-Waye
CMO
Sell
7,825 $5.24

7,825

$5.24

$41,003

Jan 10, 2023

Plavsic Mark

Plavsic Mark
Chief Technical Officer
Sell
3,418 $5.24

3,418

$5.24

$17,910

Aug 18, 2022

Dulac Edward J III

Dulac Edward J III
CFO
Sell
4,703 $29.75

4,703

$29.75

$139,914

Aug 18, 2022

Dulac Edward J III

Dulac Edward J III
CFO
Sell
432 $30.41

432

$30.41

$13,137

Jul 22, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,923 $31.33

2,923

$31.33

$91,578

Jul 22, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,703 $32.61

2,703

$32.61

$88,145

Jul 22, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
620 $33.28

620

$33.28

$20,634

Jul 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
10,829 $32.54

10,829

$32.54

$352,376

Jul 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
19,171 $33.07

19,171

$33.07

$633,985

Jul 07, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
17,158 $30.23

17,158

$30.23

$518,686

Jul 06, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
7,842 $30.07

7,842

$30.07

$235,809

Jul 05, 2022

Plavsic Mark

Plavsic Mark
Chief Technical Officer
Sell
3,719 $24.61

3,719

$24.61

$91,525

Jun 07, 2022

Agarwal Shefali

Agarwal Shefali
Sell
841 $21.89

841

$21.89

$18,409

Jun 03, 2022

Agarwal Shefali

Agarwal Shefali
Sell
807 $22.80

807

$22.80

$18,400

Jun 03, 2022

HERSHBERG ROBERT

HERSHBERG ROBERT
Sell
672 $22.75

672

$22.75

$15,288

Jun 03, 2022

Jooss Karin

Jooss Karin
Sell
1,483 $22.82

1,483

$22.82

$33,842

Jun 03, 2022

COUGHLIN TIMOTHY

COUGHLIN TIMOTHY
Sell
1,439 $22.81

1,439

$22.81

$32,824

Jun 03, 2022

MENDLEIN JOHN

MENDLEIN JOHN
Sell
1,364 $22.79

1,364

$22.79

$31,086

Jun 01, 2022

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
25,000 $22.96

25,000

$22.96

$574,000

Apr 22, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
9,162 $34.54

9,162

$34.54

$316,455

Apr 22, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
838 $35.15

838

$35.15

$29,456

Apr 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
22,715 $34.57

22,715

$34.57

$785,258

Apr 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
4,062 $35.73

4,062

$35.73

$145,135

Apr 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,220 $36.70

2,220

$36.70

$81,474

Apr 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
1,003 $37.90

1,003

$37.90

$38,014

Apr 19, 2022

Chu Yu-Waye

Chu Yu-Waye
CMO
Sell
4,062 $35.37

4,062

$35.37

$143,673

Mar 14, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
16,678 $30.36

16,678

$30.36

$506,344

Mar 14, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
3,067 $31.66

3,067

$31.66

$97,101

Mar 14, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
2,195 $32.49

2,195

$32.49

$71,316

Mar 14, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
2,960 $33.30

2,960

$33.30

$98,568

Mar 14, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
100 $34.04

100

$34.04

$3,404

Mar 10, 2022

MENDLEIN JOHN

MENDLEIN JOHN
Sell
19,493 $34.73

19,493

$34.73

$676,992

Mar 10, 2022

MENDLEIN JOHN

MENDLEIN JOHN
Sell
12,069 $35.48

12,069

$35.48

$428,208

Jan 21, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
10,000 $38.02

10,000

$38.02

$380,200

Jan 20, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
30,000 $40.21

30,000

$40.21

$1,206,300

Jan 11, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
10,047 $48.50

10,047

$48.50

$487,280

Jan 11, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
4,519 $49.07

4,519

$49.07

$221,747

Jan 11, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
4,152 $48.44

4,152

$48.44

$201,123

Jan 11, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
418 $49.12

418

$49.12

$20,532

Jan 11, 2022

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
4,883 $48.46

4,883

$48.46

$236,630

Jan 11, 2022

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
536 $49.15

536

$49.15

$26,344

Jan 11, 2022

Dulac Edward J III

Dulac Edward J III
CFO
Sell
1,380 $48.25

1,380

$48.25

$66,585

Jan 11, 2022

Dulac Edward J III

Dulac Edward J III
CFO
Sell
390 $49.16

390

$49.16

$19,172

Jan 11, 2022

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
3,547 $48.44

3,547

$48.44

$171,817

Jan 11, 2022

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
418 $49.10

418

$49.10

$20,524

Jan 10, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
13,161 $46.36

13,161

$46.36

$610,144

Jan 10, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
20,894 $47.17

20,894

$47.17

$985,570

Jan 10, 2022

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
101 $47.72

101

$47.72

$4,820

Jan 10, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
5,245 $46.33

5,245

$46.33

$243,001

Jan 10, 2022

Valamehr Bahram

Valamehr Bahram
Chief R&D Officer
Sell
351 $47.17

351

$47.17

$16,557

Jan 10, 2022

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
7,095 $46.37

7,095

$46.37

$328,995

Jan 10, 2022

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
643 $47.15

643

$47.15

$30,317

Dec 20, 2021

Dulac Edward J III

Dulac Edward J III
CFO
Sell
15,977 $60.00

15,977

$60.00

$958,620

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
2,097 $49.32

2,097

$49.32

$103,424

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
900 $50.42

900

$50.42

$45,378

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
1,045 $51.08

1,045

$51.08

$53,379

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
1,822 $52.37

1,822

$52.37

$95,418

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
1,031 $53.66

1,031

$53.66

$55,323

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
600 $54.58

600

$54.58

$32,748

Dec 10, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
5 $55.54

5

$55.54

$278

Nov 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
20,000 $54.27

20,000

$54.27

$1,085,400

Oct 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
30,000 $58.88

30,000

$58.88

$1,766,400

Oct 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
15,235 $59.82

15,235

$59.82

$911,358

Oct 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
14,765 $60.63

14,765

$60.63

$895,202

Oct 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
16,312 $58.03

16,312

$58.03

$946,634

Oct 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
21,844 $58.96

21,844

$58.96

$1,287,966

Oct 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
11,844 $59.68

11,844

$59.68

$706,862

Sep 28, 2021

Dulac Edward J III

Dulac Edward J III
CFO
Sell
19,460 $62.53

19,460

$62.53

$1,216,834

Sep 13, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
15,809 $65.94

15,809

$65.94

$1,042,414

Sep 13, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
8,391 $66.84

8,391

$66.84

$560,879

Sep 13, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
800 $67.46

800

$67.46

$53,965

Aug 19, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
20,000 $88.01

20,000

$88.01

$1,760,204

Aug 19, 2021

Dulac Edward J III

Dulac Edward J III
CFO
Sell
1,937 $87.90

1,937

$87.90

$170,262

Aug 19, 2021

Dulac Edward J III

Dulac Edward J III
CFO
Sell
1,474 $88.65

1,474

$88.65

$130,670

Aug 19, 2021

Dulac Edward J III

Dulac Edward J III
CFO
Sell
63 $90.00

63

$90.00

$5,670

Jul 23, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
30,000 $85.28

30,000

$85.28

$2,558,538

Jul 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
6,627 $85.38

6,627

$85.38

$565,821

Jul 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
21,773 $86.19

21,773

$86.19

$1,876,711

Jul 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
1,600 $86.90

1,600

$86.90

$139,044

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
100 $84.83

100

$84.83

$8,483

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
200 $86.56

200

$86.56

$17,312

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
1,145 $87.90

1,145

$87.90

$100,640

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
400 $88.93

400

$88.93

$35,573

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
707 $90.30

707

$90.30

$63,843

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
225 $91.06

225

$91.06

$20,490

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
432 $92.26

432

$92.26

$39,856

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
400 $93.31

400

$93.31

$37,323

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
1,825 $94.63

1,825

$94.63

$172,694

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
100 $95.30

100

$95.30

$9,530

Jul 01, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
50,000 $84.56

50,000

$84.56

$4,228,000

Jun 14, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
16,380 $89.11

16,380

$89.11

$1,459,587

Jun 14, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
8,220 $89.68

8,220

$89.68

$737,155

Jun 14, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
400 $90.76

400

$90.76

$36,303

May 20, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
20,000 $77.16

20,000

$77.16

$1,543,292

Apr 23, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
30,000 $85.24

30,000

$85.24

$2,557,284

Apr 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
30,000 $85.54

30,000

$85.54

$2,566,212

Apr 16, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
875 $81.80

875

$81.80

$71,575

Apr 16, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
900 $82.91

900

$82.91

$74,619

Apr 16, 2021

Chu Yu-Waye

Chu Yu-Waye
Senior VP Clinical Development
Sell
1,500 $84.41

1,500

$84.41

$126,615

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
1,000 $80.49

1,000

$80.49

$80,494

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
8,220 $81.48

8,220

$81.48

$669,731

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
4,556 $82.69

4,556

$82.69

$376,714

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
3,490 $83.40

3,490

$83.40

$291,080

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
2,200 $84.48

2,200

$84.48

$185,865

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
4,835 $85.98

4,835

$85.98

$415,733

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
5,299 $86.76

5,299

$86.76

$459,733

Apr 01, 2021

TAHL CINDY

TAHL CINDY
See Remarks
Sell
400 $87.45

400

$87.45

$34,979

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
3,298 $78.60

3,298

$78.60

$259,236

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
4,627 $79.58

4,627

$79.58

$368,236

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
5,174 $80.73

5,174

$80.73

$417,722

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,993 $81.60

2,993

$81.60

$244,224

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,480 $83.46

2,480

$83.46

$206,989

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,728 $84.20

2,728

$84.20

$229,705

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,900 $85.50

2,900

$85.50

$247,956

Mar 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
800 $86.70

800

$86.70

$69,360

Feb 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
1,401 $99.08

1,401

$99.08

$138,817

Feb 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
1,848 $100.48

1,848

$100.48

$185,691

Feb 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,602 $101.42

2,602

$101.42

$263,883

Feb 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
8,602 $102.26

8,602

$102.26

$879,661

Feb 18, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
5,547 $103.16

5,547

$103.16

$572,206

Jan 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
12,767 $97.23

12,767

$97.23

$1,241,383

Jan 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
7,638 $98.45

7,638

$98.45

$751,952

Jan 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
6,520 $99.35

6,520

$99.35

$647,732

Jan 22, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
3,075 $100.01

3,075

$100.01

$307,545

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,540 $100.16

2,540

$100.16

$254,411

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
5,993 $101.09

5,993

$101.09

$605,808

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
3,300 $101.91

3,300

$101.91

$336,314

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
3,895 $103.23

3,895

$103.23

$402,086

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
9,156 $104.13

9,156

$104.13

$953,438

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
4,271 $105.25

4,271

$105.25

$449,517

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
645 $106.03

645

$106.03

$68,392

Jan 21, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
200 $106.96

200

$106.96

$21,391

Jan 19, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
15,835 $114.11

15,835

$114.11

$1,806,959

Jan 19, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
14,944 $115.09

14,944

$115.09

$1,719,935

Jan 19, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
4,021 $115.97

4,021

$115.97

$466,333

Jan 19, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
200 $117.07

200

$117.07

$23,413

Jan 11, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
1,332 $111.62

1,332

$111.62

$148,673

Jan 11, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
1,050 $110.76

1,050

$110.76

$116,296

Jan 11, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
871 $109.65

871

$109.65

$95,509

Jan 11, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
3,515 $111.62

3,515

$111.62

$392,330

Jan 11, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,772 $110.76

2,772

$110.76

$307,021

Jan 11, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
2,300 $109.65

2,300

$109.65

$252,204

Jan 11, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
1,332 $111.62

1,332

$111.62

$148,673

Jan 11, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
1,051 $110.76

1,051

$110.76

$116,407

Jan 11, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
871 $109.65

871

$109.65

$95,509

Jan 11, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
1,332 $111.62

1,332

$111.62

$148,673

Jan 11, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
1,050 $110.76

1,050

$110.76

$116,296

Jan 11, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
872 $109.65

872

$109.65

$95,618

Jan 08, 2021

Redmile Group, LLC

Redmile Group, LLC
Buy
327,485 $85.50

327,485

$85.50

$27,999,968

Jan 08, 2021

Redmile Group, LLC

Redmile Group, LLC
Buy
257,310 $85.50

257,310

$85.50

$9,876,150

Jan 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,755 $117.60

2,755

$117.60

$323,985

Jan 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
2,451 $117.15

2,451

$117.15

$287,144

Jan 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
872 $115.80

872

$115.80

$100,977

Jan 08, 2021

Shoemaker Daniel D

Shoemaker Daniel D
Chief Scientific Officer
Sell
151 $114.76

151

$114.76

$17,328

Jan 08, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
26,904 $117.60

26,904

$117.60

$3,163,883

Jan 08, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
23,932 $117.15

23,932

$117.15

$2,803,730

Jan 08, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
8,515 $115.80

8,515

$115.80

$986,028

Jan 08, 2021

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
1,469 $114.76

1,469

$114.76

$168,575

Jan 08, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
2,756 $117.60

2,756

$117.60

$324,103

Jan 08, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
2,451 $117.15

2,451

$117.15

$287,144

Jan 08, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
872 $115.80

872

$115.80

$100,977

Jan 08, 2021

Valamehr Bahram

Valamehr Bahram
Chief Development Officer
Sell
151 $114.76

151

$114.76

$17,328

Jan 08, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
2,755 $117.60

2,755

$117.60

$323,985

Jan 08, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
2,451 $117.15

2,451

$117.15

$287,144

Jan 08, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
872 $115.80

872

$115.80

$100,977

Jan 08, 2021

TAHL CINDY

TAHL CINDY
General Counsel and Secretary
Sell
151 $114.76

151

$114.76

$17,328

Dec 17, 2020

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
3,168 $90.98

3,168

$90.98

$288,229

Dec 17, 2020

Wolchko J Scott

Wolchko J Scott
President and CEO
Sell
13,936 $91.77

13,936

$91.77

$1,278,914

TOP